The transcription factor Gli3 is acting mainly as a transcriptional repressor in the Sonic hedgehog signal transduction pathway.Gli3 contains a repressor domain in its N-terminus from residue G106 to E236.In this study we have characterized the intracellular structure of the Gli3 repressor domain using a combined bioinformatics Outdoor Bench and ex
Estimation of black-box functions often requires evaluating an extensive number of expensive noisy points.Learning algorithms can actively compare the similarity between the evaluated and unevaluated points to determine the most informative subsequent points for efficient estimation of expensive functions in a sequential procedure.In this paper, we
Abstract Background Central sensitization is one of the characters of chronic migraine (CM).Aberrant synaptic plasticity can induce central sensitization.Oxytocin (OT), which is a hypothalamic hormone, plays an important antinociceptive role.However, the antinociceptive effect of OT and the underlying mechanism in CM remains unclear.Therefore, we e